PAXX

Across TCGA cell cohorts, PAXX mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAXX-associated genes across cancer lineages are CYP39A1, CPXCR1, and PCDH19. Each is linked with PAXX in more than 1 cancer types. Because this analysis shows association rather than direction, both PAXX-to-partner and partner-to-PAXX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP39A1 grouped by PAXX-low versus PAXX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXX→partner) and Y-score (partner→PAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP39A1 →	+0.146	+3.091	<.001	.006	3	1
BLOOD_Leukemia	CPXCR1 →	+0.074	+2.971	<.001	.008	3	1
BLOOD_Leukemia	PCDH19 →	+0.198	+3.540	.001	.005	3	1
BLOOD_Leukemia	TDRD6 →	+0.059	+3.607	.007	.004	3	1
BLOOD_Leukemia	RGS7 →	+0.270	+3.091	<.001	.006	3	1
BLOOD_Leukemia	AQP12A →	+0.100	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CYP39A1 by PAXX expression — BLOOD_Leukemia

Explore this box plot interactively →