PAXIP1

Across TCGA pan-cancer cohorts, PAXIP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PAXIP1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PAXIP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PAXIP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, COAD, and PDAC are the cancer types where PAXIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.968	0.734	.001	54	view →
COAD	DFS	Median	II,III,IV	1.000	0.894	.024	30	view →
PDAC	DFS	Tertile	All	0.917	0.630	.007	16	view →
CCRCC	DFS	Quartile	All	0.950	0.603	.003	10	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.589	.024	8	view →
HNSC	OS	Quartile	IV	0.739	0.936	.036	2	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	2	view →
GBM	OS	Median	All	0.503	0.293	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PAXIP1–LSCC (OS)

Open the LSCC breakdown →