PAXIP1

Across TCGA pan-cancer cohorts, PAXIP1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PAXIP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAXIP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAXIP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, BLCA, and THCA are the cancer types where PAXIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAXIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.894	<.001	12	view →
BLCA	Male	III,IV	+0.787	<.001	12	view →
THCA	All	IV	−0.902	<.001	11	view →
HNSC	All	III,IV	+0.679	<.001	11	view →
KIRC	Male	All	+0.341	<.001	11	view →
KIRP	All	IV	+0.929	.001	9	view →
LIHC	Female	II,III,IV	+0.906	<.001	9	view →
LUAD	Male	II,III,IV	+0.730	<.001	9	view →
STAD	Male	II,III,IV	+0.871	<.001	8	view →
BRCA	All	II,III,IV	+0.611	<.001	8	view →
LUSC	Female	All	+0.908	<.001	7	view →
CHOL	Male	All	+1.721	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PAXIP1–COAD

Open the COAD breakdown →