PAXIP1

Across TCGA patient cohorts, PAXIP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAXIP1-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with PAXIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAXIP1-to-partner and partner-to-PAXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PAXIP1-low versus PAXIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXIP1→partner) and Y-score (partner→PAXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.138	+2.598	.023	.005	3	2
UCEC	A-Raf_pS299 →	-0.086	-2.321	.011	.005	3	2
UCEC	ERK2 →	+0.143	+1.514	.010	.014	3	2
UCEC	MEK1 →	+0.348	+2.201	<.001	<.001	3	2
UCEC	Notch1 →	+0.135	+1.536	<.001	.002	3	2
UCEC	PCNA →	+0.144	+1.347	.020	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by PAXIP1 expression — UCEC

Explore this box plot interactively →