PAXIP1

Across TCGA cell cohorts, PAXIP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,965 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAXIP1-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Pre-mRNA catabolic process, and DNA-templated DNA replication. Each is linked with PAXIP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PAXIP1-to-partner and partner-to-PAXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by PAXIP1-low versus PAXIP1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXIP1→partner) and Y-score (partner→PAXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.155	+0.850	<.001	<.001	3	19
BONE	Pre-mRNA catabolic process →	+0.163	+0.947	.001	<.001	3	17
BLOOD_Myeloma	DNA-templated DNA replication →	+0.146	+1.480	<.001	<.001	3	17
BONE	DNA strand elongation involved in DNA replication →	+0.210	+1.156	<.001	<.001	3	17
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.103	+1.012	<.001	.004	3	17
LUNG_NSCLC_LUSC	Regulation of isotype switching to IgG isotypes →	+0.145	+1.087	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,965 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by PAXIP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →