PAXIP1

Across TCGA cell cohorts, PAXIP1 mutation is significantly associated with the RNA expression of many other genes, with 895 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAXIP1-associated genes across cancer lineages are C8A, F11, and PGK2. Each is linked with PAXIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAXIP1-to-partner and partner-to-PAXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8A grouped by PAXIP1-low versus PAXIP1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXIP1→partner) and Y-score (partner→PAXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C8A →	+0.546	+3.632	.005	.009	3	2
LARGE_INTESTINE	F11 →	+0.026	+2.397	.007	.003	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
SOFT_TISSUE	SSX7 →	+0.019	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUSC	USP17L15 →	+0.006	+4.643	<.001	.008	3	1
URINARY_TRACT	OPN1MW2 →	+0.020	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 895 associations by consensus.

C8A by PAXIP1 expression — STOMACH

Explore this box plot interactively →