PAXIP1-DT

Across TCGA pan-cancer cohorts, PAXIP1-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PAXIP1-DT data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PAXIP1-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PAXIP1-DT expression acts as an unfavorable survival marker, although some lineages such as OV and STAD show a favorable association.

OV, STAD, and BRCA are the cancer types where PAXIP1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.610	0.473	<.001	82	view →
STAD	OS	Median	All	0.827	0.621	.003	36	view →
BRCA	OS	Tertile	All	0.952	0.893	.002	31	view →
UVM	DFS	Tertile	III,IV	0.275	0.860	.003	26	view →
HNSC	OS	Median	III,IV	0.678	0.572	.017	26	view →
KICH	OS	Tertile	All	0.795	1.000	.013	25	view →
LUSC	OS	Quartile	All	0.862	0.710	.002	15	view →
THYM	OS	Median	All	1.000	0.664	.007	14	view →
LGG	OS	Tertile	All	0.736	0.851	.006	14	view →
ESCA	DFS	Median	II,III,IV	0.407	0.563	.022	13	view →
LUAD	OS	Median	III,IV	0.748	0.564	.031	13	view →
UCS	OS	Tertile	IV	1.000	0.288	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PAXIP1-DT–OV (DFS)

Open the OV breakdown →