PAXIP1-DT

Across TCGA pan-cancer cohorts, PAXIP1-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PAXIP1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAXIP1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAXIP1-DT is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where PAXIP1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAXIP1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.882	<.001	8	view →
BLCA	Female	III,IV	+0.919	.001	7	view →
LIHC	Female	All	+0.568	<.001	7	view →
THCA	Male	All	−0.480	<.001	6	view →
HNSC	Male	IV	+1.220	.003	4	view →
KIRC	All	All	−0.262	.002	4	view →
BRCA	Female	All	−0.206	.021	4	view →
CHOL	All	All	+1.312	<.001	3	view →
LUSC	All	All	+0.461	.001	3	view →
KIRP	All	II,III,IV	+0.459	.021	3	view →
LUAD	All	IV	+1.004	.011	2	view →
READ	Female	All	+0.968	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PAXIP1-DT–COAD

Open the COAD breakdown →