PAXBP1

Across TCGA patient cohorts, PAXBP1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,704 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAXBP1-associated genes across cancer lineages are NEK2, KIF14, and DNA2. Each is linked with PAXBP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PAXBP1-to-partner and partner-to-PAXBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAXBP1 versus NEK2 in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXBP1→partner) and Y-score (partner→PAXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEK2 →	+1.004	+0.234	<.001	<.001	3	7
BRCA	KIF14 →	+0.866	+0.219	<.001	.001	3	7
LSCC	DNA2 →	+0.745	+0.260	<.001	<.001	3	7
GBM	EME1 →	+0.740	+0.217	<.001	.001	3	7
LSCC	SMC4 →	+1.163	+0.332	<.001	<.001	3	6
BRCA	CENPF →	+1.022	+0.289	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,704 associations by consensus.

PAXBP1 vs NEK2 — BRCA

Explore this scatter interactively →