Across TCGA patient cohorts, PAX9 mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX9-associated genes across cancer lineages are RN7SKP12, PPBPP1, and RNY4P14. Each is linked with PAX9 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX9-to-partner and partner-to-PAX9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX9→partner) and Y-score (partner→PAX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP12 →	+0.203	+2.966	<.001	.002	3	3
SKCM	PPBPP1 →	+0.107	+4.900	<.001	.002	3	2
CESC	RNY4P14 →	+0.345	+5.144	<.001	.003	3	2
CESC	MIR1203 →	+0.741	+4.653	<.001	.004	3	2
CESC	HMGB1P48 →	+0.073	+4.320	.001	.007	3	2
CESC	ASH2LP2 →	+0.030	+5.424	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

Exploration

PAX9 survival (RNA) · tumor vs normal (RNA) · all PAX9 data types