PAX6

Across TCGA patient cohorts, PAX6 mutation is significantly associated with the RNA expression of many other genes, with 3,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX6-associated genes across cancer lineages are UBAC1, RNA5SP521, and MED27. Each is linked with PAX6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAX6-to-partner and partner-to-PAX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBAC1 grouped by PAX6-low versus PAX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX6→partner) and Y-score (partner→PAX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBAC1 →	+0.291	+1.734	.002	<.001	3	4
BLCA	RNA5SP521 →	+0.447	+4.973	<.001	.009	3	3
UCEC	MED27 →	+0.369	+1.922	<.001	<.001	3	3
UCEC	ZMYND19 →	+0.517	+2.710	<.001	<.001	3	3
UCEC	FEN1 →	+0.603	+1.890	<.001	<.001	3	3
UCEC	RPS19BP1 →	+0.384	+2.094	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,937 associations by consensus.

UBAC1 by PAX6 expression — UCEC

Explore this box plot interactively →