PAX6

Across TCGA pan-cancer cohorts, PAX6 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PAX6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PAX6 RNA is repressed in tumor relative to normal tissue. In most cancer types PAX6 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and HNSC are the cancer types where PAX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.454	<.001	11	view →
LUAD	Female	III,IV	−0.686	<.001	9	view →
HNSC	All	III,IV	+0.502	<.001	8	view →
KICH	Female	All	−0.453	<.001	6	view →
LIHC	All	All	+0.179	.001	6	view →
LUSC	All	All	+0.472	.001	4	view →
CHOL	All	All	+0.932	.001	3	view →
BRCA	All	III,IV	−0.213	.001	2	view →
LUSC	All	III,IV	−0.341	.038	1	view →
KIRP	Male	All	−0.211	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

PAX6–THCA

Open the THCA breakdown →