PAX6

Across TCGA patient cohorts, PAX6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX6-associated genes across cancer lineages are eEF2, ATM, and PCNA. Each is linked with PAX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX6-to-partner and partner-to-PAX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PAX6-low versus PAX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX6→partner) and Y-score (partner→PAX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.270	+1.137	.016	.041	3	3
UCEC	ATM →	-0.571	-3.074	<.001	<.001	3	3
UCEC	PCNA →	+0.178	+2.000	.008	.029	3	2
UCEC	TFRC →	+0.381	+1.584	.022	.005	3	2
UCEC	Cyclin-B1 →	+0.545	+2.700	.002	.005	3	2
UCEC	Di-Ras3 →	-0.155	-3.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eEF2 by PAX6 expression — UCEC

Explore this box plot interactively →