PAX6

Across TCGA cell cohorts, PAX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,538 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PAX6-associated GO terms across cancer lineages are Pancreatic A cell differentiation, Cornea development in camera-type eye, and Negative regulation of post-translational protein modification. Each is linked with PAX6 in more than 15 cancer types. Because this analysis shows association rather than direction, both PAX6-to-partner and partner-to-PAX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pancreatic A cell differentiation grouped by PAX6-low versus PAX6-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX6→partner) and Y-score (partner→PAX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Pancreatic A cell differentiation →	+1.875	+2.432	<.001	<.001	3	16
LIVER	Cornea development in camera-type eye →	+1.708	+3.739	<.001	<.001	3	14
LIVER	Negative regulation of post-translational protein modification →	+0.068	+1.975	<.001	.006	3	9
LIVER	Regulation of cardiac muscle tissue development →	+1.809	+3.659	<.001	<.001	3	8
URINARY_TRACT	Positive regulation of telomere maintenance →	+0.047	+2.217	.007	.001	3	8
BREAST	Negative regulation of protein modification by small protein conjugation or removal →	+0.084	+2.160	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,538 associations by consensus.

Pancreatic A cell differentiation by PAX6 expression — CNS

Explore this box plot interactively →