PAX6

Across TCGA cell cohorts, PAX6 mutation is significantly associated with the RNA expression of many other genes, with 739 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAX6-associated genes across cancer lineages are DUX4, SSX7, and SLC5A7. Each is linked with PAX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX6-to-partner and partner-to-PAX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUX4 grouped by PAX6-low versus PAX6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX6→partner) and Y-score (partner→PAX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DUX4 →	+0.032	+2.628	.001	.002	3	2
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	SLC5A7 →	+0.068	+4.299	<.001	.001	3	1
LUNG_NSCLC_LUAD	CPN1 →	+0.176	+3.795	.007	.004	3	1
LUNG_NSCLC_LUAD	HPGDS →	+0.042	+3.700	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.011	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

DUX4 by PAX6 expression — LARGE_INTESTINE

Explore this box plot interactively →