PAX4

Across TCGA patient cohorts, PAX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,328 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible PAX4-associated GO terms across cancer lineages are Positive regulation of DNA repair, Establishment of protein localization to mitochondrial membrane, and Protein localization to mitochondrion. Each is linked with PAX4 in more than 12 cancer types. Because this analysis shows association rather than direction, both PAX4-to-partner and partner-to-PAX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by PAX4-low versus PAX4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX4→partner) and Y-score (partner→PAX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of DNA repair →	+0.040	+0.442	.003	.002	3	13
HNSC	Establishment of protein localization to mitochondrial membrane →	+0.040	+0.016	<.001	<.001	3	11
ESCA	Protein localization to mitochondrion →	+0.041	+0.379	<.001	<.001	3	11
HNSC	DNA conformation change →	+0.040	+0.017	<.001	<.001	3	11
STAD	Amino acid activation →	+0.052	+0.278	<.001	<.001	3	11
ESCA	Positive regulation of DNA metabolic process →	+0.040	+0.410	.007	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,328 associations by consensus.

Positive regulation of DNA repair by PAX4 expression — ESCA

Explore this box plot interactively →