PAX4

Across TCGA patient cohorts, PAX4 protein abundance is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAX4-associated genes across cancer lineages are PFDN4, RPRD1B, and METTL4. Each is linked with PAX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX4-to-partner and partner-to-PAX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAX4 versus PFDN4 in GBM, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX4→partner) and Y-score (partner→PAX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PFDN4 →	-0.630	-0.581	<.001	.001	3	1
GBM	RPRD1B →	-0.416	-0.482	.001	.005	3	1
GBM	METTL4 →	-0.588	-0.625	.003	.008	3	1
GBM	AMMECR1 →	-0.582	-0.525	<.001	.005	3	1
GBM	XIAP →	-0.354	-0.448	<.001	.003	3	1
GBM	FMR1 →	-0.495	-0.557	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

PAX4 vs PFDN4 — GBM

Explore this scatter interactively →