PAX4

Across TCGA patient cohorts, PAX4 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX4-associated genes across cancer lineages are PDK1_pS241, Shc_pY317, and LKB1. Each is linked with PAX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX4-to-partner and partner-to-PAX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by PAX4-low versus PAX4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX4→partner) and Y-score (partner→PAX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PDK1_pS241 →	+0.139	+2.179	.040	.035	3	2
UCEC	Shc_pY317 →	-0.182	-1.906	.001	.015	3	2
SKCM	LKB1 →	-0.132	-3.321	.028	.010	3	2
UCEC	JNK2 →	+0.231	+1.847	.001	.008	3	2
UCEC	Annexin-1 →	+0.624	+2.242	.001	.005	3	2
UCEC	STAT5a →	+0.358	+2.000	.014	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDK1_pS241 by PAX4 expression — LUSC

Explore this box plot interactively →