PAX4

Across TCGA cell cohorts, PAX4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PAX4-associated genes across cancer lineages are ASB17, SERPINA7, and OR7G2. Each is linked with PAX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX4-to-partner and partner-to-PAX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by PAX4-low versus PAX4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX4→partner) and Y-score (partner→PAX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.013	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
CNS	ODF4 →	+0.050	+4.169	<.001	.008	3	1
CNS	AMY1C →	+0.088	+4.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ASB17 by PAX4 expression — OVARY

Explore this box plot interactively →