PAX2

Across TCGA patient cohorts, PAX2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX2-associated genes across cancer lineages are ATM, ERK2, and JNK_pT183_Y185. Each is linked with PAX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX2-to-partner and partner-to-PAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PAX2-low versus PAX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX2→partner) and Y-score (partner→PAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.364	-3.156	.046	.018	3	3
UCEC	ERK2 →	+0.240	+2.700	.001	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.163	-2.459	.016	.019	3	2
UCEC	MEK1 →	+0.442	+3.807	.002	<.001	3	2
UCEC	Smad3 →	+0.140	+2.000	.020	.030	3	2
UCEC	STAT3_pY705 →	-0.398	-3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by PAX2 expression — UCEC

Explore this box plot interactively →