PAX2

Across TCGA pan-cancer cohorts, PAX2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PAX2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PAX2 RNA is repressed in tumor relative to normal tissue. In most cancer types PAX2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, BRCA, and KIRC are the cancer types where PAX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−4.552	<.001	10	view →
BRCA	All	III,IV	+0.671	<.001	6	view →
KIRC	All	II,III,IV	−0.649	.005	6	view →
COAD	All	All	+0.043	.014	3	view →
KIRP	All	IV	+0.722	.015	2	view →
PRAD	All	All	−0.506	.016	2	view →
THCA	Male	II,III,IV	−0.125	.018	2	view →
LUAD	Male	All	+0.018	.024	2	view →
LUSC	All	All	+0.296	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PAX2–KICH

Open the KICH breakdown →