PAX2

Across TCGA cell cohorts, PAX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,828 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PAX2-associated GO terms across cancer lineages are Positive regulation of metanephros development, Regulation of metanephric glomerulus development, and Positive regulation of metanephric glomerulus development. Each is linked with PAX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PAX2-to-partner and partner-to-PAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of metanephros development grouped by PAX2-low versus PAX2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX2→partner) and Y-score (partner→PAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of metanephros development →	+2.115	+3.259	<.001	<.001	3	12
KIDNEY	Regulation of metanephric glomerulus development →	+2.115	+3.259	<.001	<.001	3	12
KIDNEY	Positive regulation of metanephric glomerulus development →	+2.115	+3.259	<.001	<.001	3	12
BREAST	Regulation of metanephric nephron tubule epithelial cell differentiation →	-0.277	-0.806	<.001	<.001	3	7
SOFT_TISSUE	Optic nerve development →	-0.308	-1.263	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Positive regulation of glomerulus development →	-0.848	-0.404	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

Positive regulation of metanephros development by PAX2 expression — KIDNEY

Explore this box plot interactively →