PAX2

Across TCGA cell cohorts, PAX2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAX2-associated genes across cancer lineages are KLRF2, OR2V1, and LALBA. Each is linked with PAX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX2-to-partner and partner-to-PAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRF2 grouped by PAX2-low versus PAX2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX2→partner) and Y-score (partner→PAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KLRF2 →	+0.040	+4.371	.003	.005	3	1
LARGE_INTESTINE	OR2V1 →	+0.042	+4.095	.004	.009	3	1
BLOOD_Leukemia	LALBA →	+0.038	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KLRF2 by PAX2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →