PAX1

Across TCGA patient cohorts, PAX1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX1-associated genes across cancer lineages are MEK1, HER3_pY1289, and eIF4E. Each is linked with PAX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX1-to-partner and partner-to-PAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PAX1-low versus PAX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX1→partner) and Y-score (partner→PAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.296	+2.115	.027	.017	3	3
LUSC	HER3_pY1289 →	+0.105	+2.816	.039	.036	3	2
STAD	eIF4E →	+0.238	+3.169	.007	.019	3	2
UCEC	p90 RSK →	+0.149	+2.125	.034	.010	3	2
UCEC	PRDX1 →	+0.204	+2.115	.006	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.802	+2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by PAX1 expression — UCEC

Explore this box plot interactively →