PAX1

Across TCGA pan-cancer cohorts, PAX1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PAX1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PAX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PAX1 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

UCEC, KIRC, and BLCA are the cancer types where PAX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.412	0.734	<.001	92	view →
KIRC	DFS	Median	All	0.493	0.710	<.001	82	view →
BLCA	OS	Tertile	All	0.303	0.476	.005	64	view →
LIHC	DFS	Tertile	All	0.390	0.569	.002	42	view →
LUAD	DFS	Tertile	III,IV	0.509	0.693	.011	34	view →
LGG	OS	Median	All	0.931	0.854	<.001	27	view →
KIRP	DFS	Quartile	All	0.809	0.931	.002	24	view →
PAAD	OS	Tertile	II,III,IV	0.654	0.424	.007	20	view →
LUSC	OS	Tertile	III,IV	0.574	0.754	.008	18	view →
BRCA	DFS	Quartile	IV	0.800	0.261	.016	14	view →
STAD	DFS	Quartile	IV	0.531	0.096	.013	12	view →
TGCT	DFS	Quartile	All	0.525	0.892	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PAX1–UCEC (OS)

Open the UCEC breakdown →