PAX1

Across TCGA cell cohorts, PAX1 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAX1-associated genes across cancer lineages are PRAMEF20, TCP10L2, and DPH5. Each is linked with PAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX1-to-partner and partner-to-PAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by PAX1-low versus PAX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX1→partner) and Y-score (partner→PAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF20 →	+0.210	+3.099	<.001	.003	3	2
LUNG_NSCLC_LUAD	TCP10L2 →	+0.038	+3.472	<.001	.004	3	2
LARGE_INTESTINE	DPH5 →	+0.759	+3.169	<.001	.009	3	2
LARGE_INTESTINE	ECE2 →	+0.175	+2.317	.006	.004	3	2
LARGE_INTESTINE	ACER1 →	+0.084	+2.630	<.001	.001	3	2
LUNG_SCLC	PPBP →	+0.325	+3.058	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

PRAMEF20 by PAX1 expression — LUNG_SCLC

Explore this box plot interactively →