PAWR

Across TCGA pan-cancer cohorts, PAWR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAWR data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PAWR mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PAWR expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where PAWR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.815	0.382	.008	13	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
HNSC	OS	Tertile	All	0.638	0.842	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAWR–LUAD (OS)

Open the LUAD breakdown →