PATZ1

Across TCGA patient cohorts, PATZ1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATZ1-associated genes across cancer lineages are MEK1, MSH2, and ACC_pS79. Each is linked with PATZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATZ1-to-partner and partner-to-PATZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PATZ1-low versus PATZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATZ1→partner) and Y-score (partner→PATZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.306	+2.415	.018	.003	3	2
UCEC	MSH2 →	-0.228	-1.973	.005	.029	3	2
UCEC	ACC_pS79 →	+0.273	+1.495	.025	.034	3	1
UCEC	ACC1 →	+0.309	+3.472	.016	.002	3	1
UCEC	Notch1 →	+0.140	+2.009	.004	.017	3	1
UCEC	p62 Lck ligand →	+0.243	+2.594	.034	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by PATZ1 expression — UCEC

Explore this box plot interactively →