PATZ1

Across TCGA pan-cancer cohorts, PATZ1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PATZ1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PATZ1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PATZ1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

COAD, LIHC, and BRCA are the cancer types where PATZ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PATZ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.133	<.001	11	view →
LIHC	All	II,III,IV	+0.656	<.001	7	view →
BRCA	All	III,IV	+0.773	<.001	6	view →
KICH	All	All	−0.718	<.001	6	view →
LUAD	All	All	+0.368	.001	6	view →
CHOL	Male	All	+2.353	<.001	5	view →
HNSC	Male	III,IV	+0.748	.012	5	view →
LUSC	All	All	+0.551	<.001	5	view →
KIRC	All	II,III,IV	−0.379	<.001	5	view →
STAD	Male	II,III,IV	+1.193	<.001	4	view →
BLCA	Female	III,IV	+0.928	.035	3	view →
READ	All	III,IV	+0.964	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PATZ1–COAD

Open the COAD breakdown →