PATZ1

Across TCGA cell cohorts, PATZ1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PATZ1-associated genes across cancer lineages are FSHB, MTRNR2L6, and TFAP2D. Each is linked with PATZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATZ1-to-partner and partner-to-PATZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by PATZ1-low versus PATZ1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATZ1→partner) and Y-score (partner→PATZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
BLOOD_Lymphoma	LMX1A →	+0.042	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.099	+4.191	<.001	.007	3	1
CNS	SCGB1C1 →	+0.242	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FSHB by PATZ1 expression — CNS

Explore this box plot interactively →