PATL1

Across TCGA patient cohorts, PATL1 mutation is significantly associated with the RNA expression of many other genes, with 3,384 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATL1-associated genes across cancer lineages are RN7SL539P, RNU4-85P, and UHRF1. Each is linked with PATL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATL1-to-partner and partner-to-PATL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL539P grouped by PATL1-low versus PATL1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATL1→partner) and Y-score (partner→PATL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL539P →	+0.079	+8.471	<.001	.005	3	2
BLCA	RNU4-85P →	+0.345	+3.758	<.001	.008	3	2
UCEC	UHRF1 →	+0.941	+2.273	<.001	<.001	3	2
SKCM	CRYBB2P1 →	+0.521	+2.509	<.001	.009	3	2
SKCM	POLE2 →	+0.613	+4.031	<.001	<.001	3	2
UCEC	E2F1 →	+0.870	+3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,384 associations by consensus.

RN7SL539P by PATL1 expression — BRCA

Explore this box plot interactively →