PATL1

Across TCGA pan-cancer cohorts, PATL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PATL1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PATL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PATL1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where PATL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PATL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.302	<.001	11	view →
HNSC	All	III,IV	+1.107	<.001	11	view →
COAD	Male	II,III,IV	+0.671	<.001	11	view →
KIRC	All	All	+0.394	<.001	11	view →
KIRP	All	II,III,IV	+0.641	.003	10	view →
STAD	Male	II,III,IV	+1.309	<.001	8	view →
LUSC	Male	II,III,IV	+0.849	<.001	7	view →
UCEC	All	III,IV	+1.063	.001	6	view →
BRCA	All	II,III,IV	+0.371	<.001	6	view →
LUAD	All	II,III,IV	+0.456	.002	4	view →
CHOL	All	All	+1.068	<.001	3	view →
ESCA	Female	All	+1.509	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PATL1–BLCA

Open the BLCA breakdown →