PATL1

Across TCGA patient cohorts, PATL1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATL1-associated genes across cancer lineages are 4E-BP1_pS65, HER2_pY1248, and Rab11. Each is linked with PATL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATL1-to-partner and partner-to-PATL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by PATL1-low versus PATL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATL1→partner) and Y-score (partner→PATL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pS65 →	+0.201	+3.459	.042	.005	3	2
UCEC	HER2_pY1248 →	-0.210	-2.938	.023	<.001	3	2
UCEC	Rab11 →	-0.125	-2.070	.012	.001	3	2
UCEC	ATM →	-0.431	-1.700	.006	.042	3	2
UCEC	Caspase-8 →	-0.281	-2.459	.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.838	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

4E-BP1_pS65 by PATL1 expression — SKCM

Explore this box plot interactively →