PATL1

Across TCGA cell cohorts, PATL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PATL1-associated genes across cancer lineages are RAX2, MAGEB1, and CD300H. Each is linked with PATL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATL1-to-partner and partner-to-PATL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAX2 grouped by PATL1-low versus PATL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATL1→partner) and Y-score (partner→PATL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAX2 →	+0.075	+3.196	<.001	.007	3	1
LARGE_INTESTINE	MAGEB1 →	+0.182	+3.878	<.001	.003	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
BLOOD_Lymphoma	OXT →	+0.033	+4.523	.006	.004	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RAX2 by PATL1 expression — LARGE_INTESTINE

Explore this box plot interactively →