PATE4

Across TCGA patient cohorts, PATE4 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATE4-associated genes across cancer lineages are MIR4708, DUXAP11, and RNA5SP350. Each is linked with PATE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATE4-to-partner and partner-to-PATE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4708 grouped by PATE4-low versus PATE4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATE4→partner) and Y-score (partner→PATE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4708 →	+0.570	+7.731	<.001	.009	3	1
BRCA	DUXAP11 →	+0.079	+7.731	<.001	.009	3	1
BRCA	RNA5SP350 →	+0.542	+8.055	<.001	.007	3	1
BRCA	RNY1P8 →	+0.531	+7.731	<.001	.009	3	1
BRCA	RNU6-995P →	+0.408	+8.471	<.001	.005	3	1
BRCA	MIR1197 →	+0.396	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

MIR4708 by PATE4 expression — BRCA

Explore this box plot interactively →