PATE1

Across TCGA patient cohorts, PATE1 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PATE1-associated genes across cancer lineages are NDUFB10P1, PRPF19P1, and RPL31P50. Each is linked with PATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATE1-to-partner and partner-to-PATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFB10P1 grouped by PATE1-low versus PATE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATE1→partner) and Y-score (partner→PATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFB10P1 →	+0.099	+2.914	<.001	.006	3	2
SKCM	PRPF19P1 →	+0.304	+3.238	.001	.002	3	2
UCEC	RPL31P50 →	+0.397	+3.896	.003	.004	3	2
UCEC	SEPTIN14 →	+0.512	+3.598	.008	.009	2	2
COAD	TUBB4BP5 →	+0.283	+4.693	.006	.007	3	1
COAD	COX6B1P7 →	+0.467	+5.392	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

NDUFB10P1 by PATE1 expression — SKCM

Explore this box plot interactively →