PATE1

Across TCGA patient cohorts, PATE1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PATE1-associated genes across cancer lineages are CD8+ Tcm, CD4+ naive T-cells, and Neutrophils. Each is linked with PATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATE1-to-partner and partner-to-PATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by PATE1-low versus PATE1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATE1→partner) and Y-score (partner→PATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD8+ Tcm →	+0.058	+3.290	.027	.041	3	2
LUAD	CD4+ naive T-cells →	+0.043	+3.640	.001	.024	3	1
SKCM	Neutrophils →	+0.016	+2.176	.009	.035	3	1
SKCM	NKT →	+0.202	+2.813	.004	.037	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ Tcm by PATE1 expression — LUAD

Explore this box plot interactively →