PATE1

Across TCGA cell cohorts, PATE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 542 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible PATE1-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Autophagosome membrane docking, and Keratinocyte development. Each is linked with PATE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PATE1-to-partner and partner-to-PATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by PATE1-low versus PATE1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PATE1→partner) and Y-score (partner→PATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of protein K48-linked ubiquitination →	+0.091	+0.028	<.001	<.001	3	4
LUNG_NSCLC_LUSC	Autophagosome membrane docking →	-0.137	-0.054	<.001	.005	3	3
LUNG_NSCLC_LUSC	Keratinocyte development →	+0.384	+0.036	<.001	.001	3	3
OVARY	Negative regulation of calcium ion export across plasma membrane →	+0.047	+0.018	<.001	.007	3	3
OVARY	mRNA destabilization →	+0.037	+0.016	.006	.003	3	3
LUNG_SCLC	Regulation of spindle organization →	+0.052	+0.051	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

Regulation of protein K48-linked ubiquitination by PATE1 expression — LUNG_NSCLC_LUAD

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