Across TCGA patient cohorts, PARVB protein abundance is significantly associated with the RNA expression of many other genes, with 13,751 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PARVB-associated genes across cancer lineages are MMP19, EMP3, and SERPINE1. Each is linked with PARVB in more than 8 cancer types. Because this analysis shows association rather than direction, both PARVB-to-partner and partner-to-PARVB results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVB→partner) and Y-score (partner→PARVB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MMP19 →	+1.321	+0.450	<.001	<.001	3	9
GBM	EMP3 →	+0.797	+0.357	<.001	.002	3	8
OV	SERPINE1 →	+1.563	+0.442	<.001	<.001	3	7
BRCA	HK3 →	+0.860	+0.427	<.001	<.001	3	7
BRCA	MARCO →	+1.586	+0.397	<.001	<.001	3	7
OV	CCL4 →	+1.085	+0.470	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,751 associations by consensus.

Exploration

PARVB survival (RNA) · tumor vs normal (RNA) · all PARVB data types