Across TCGA patient cohorts, PARVB mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARVB-associated genes across cancer lineages are FOXO3a_pS318_S321, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with PARVB in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVB-to-partner and partner-to-PARVB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVB→partner) and Y-score (partner→PARVB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.159	-2.115	.003	.019	3	2
UCEC	MAPK_pT202_Y204 →	-0.521	-2.459	.011	.019	3	2
UCEC	mTOR_pS2448 →	-0.211	-3.308	.001	.009	3	2
UCEC	PDCD4 →	-0.615	-2.115	.002	.019	3	2
COAD	Raptor →	-0.247	-2.991	.013	.036	3	1
UCEC	eIF4G →	+0.307	+3.169	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PARVB survival (RNA) · tumor vs normal (RNA) · all PARVB data types