Across TCGA cell cohorts, PARVB mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARVB-associated genes across cancer lineages are OR5A2, TRIML1, and GRM6. Each is linked with PARVB in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVB-to-partner and partner-to-PARVB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVB→partner) and Y-score (partner→PARVB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5A2 →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	TRIML1 →	+0.099	+4.371	.001	.005	3	1
LARGE_INTESTINE	GRM6 →	+0.067	+3.793	.005	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ENPP6 →	+0.042	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

PARVB survival (RNA) · tumor vs normal (RNA) · all PARVB data types