PARP8

Across TCGA pan-cancer cohorts, PARP8 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PARP8 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PARP8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PARP8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD and PDAC are the cancer types where PARP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.819	0.344	.024	4	view →
PDAC	OS	Quartile	II,III,IV	0.817	0.446	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PARP8–LUAD (OS)

Open the LUAD breakdown →