PARP8

Across TCGA pan-cancer cohorts, PARP8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PARP8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PARP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PARP8 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where PARP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.937	<.001	11	view →
COAD	Male	IV	+1.606	<.001	10	view →
THCA	Male	III,IV	−1.397	<.001	10	view →
KIRP	Male	II,III,IV	+1.157	<.001	9	view →
LUSC	Male	II,III,IV	−1.098	<.001	8	view →
BRCA	Female	All	−0.345	.001	4	view →
CHOL	Female	All	+2.593	<.001	3	view →
PRAD	All	All	+0.484	<.001	2	view →
HNSC	All	All	+0.371	.015	1	view →
LUAD	All	All	+0.212	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PARP8–KIRC

Open the KIRC breakdown →