PARP8

Across TCGA patient cohorts, PARP8 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP8-associated genes across cancer lineages are ERK2, eEF2, and EGFR_pY1068. Each is linked with PARP8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PARP8-to-partner and partner-to-PARP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PARP8-low versus PARP8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP8→partner) and Y-score (partner→PARP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.180	+2.115	.048	.018	3	4
UCEC	eEF2 →	+0.329	+3.321	.008	.009	3	2
UCEC	EGFR_pY1068 →	-0.287	-2.070	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.243	-3.906	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.569	+1.926	.001	.008	3	2
UCEC	Shc_pY317 →	-0.204	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ERK2 by PARP8 expression — SKCM

Explore this box plot interactively →