PARP8

Across TCGA cell cohorts, PARP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,017 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP8-associated GO terms across cancer lineages are Protein auto-ADP-ribosylation, Regulation of protein modification by small protein conjugation or removal, and Regulation of post-translational protein modification. Each is linked with PARP8 in more than 10 cancer types. Because this analysis shows association rather than direction, both PARP8-to-partner and partner-to-PARP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein auto-ADP-ribosylation grouped by PARP8-low versus PARP8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP8→partner) and Y-score (partner→PARP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein auto-ADP-ribosylation →	+0.108	+1.082	<.001	.001	3	11
OVARY	Regulation of protein modification by small protein conjugation or removal →	+0.051	+0.952	.004	.006	3	10
BONE	Regulation of post-translational protein modification →	+0.052	+1.872	.007	.004	3	9
STOMACH	Phenol-containing compound metabolic process →	-0.073	-1.618	.002	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.071	+1.230	.004	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.062	+0.859	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,017 associations by consensus.

Protein auto-ADP-ribosylation by PARP8 expression — OVARY

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