PARP8

Across TCGA cell cohorts, PARP8 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP8-associated genes across cancer lineages are Lestaurtinib, Staurosporine, and Crizotinib. Each is linked with PARP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP8-to-partner and partner-to-PARP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lestaurtinib grouped by PARP8-low versus PARP8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP8→partner) and Y-score (partner→PARP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Lestaurtinib →	+0.604	+2.710	.014	.043	3	1
LARGE_INTESTINE	Staurosporine →	+0.470	+2.646	.046	.047	3	1
LARGE_INTESTINE	Crizotinib →	+0.412	+2.646	.045	.047	3	1
LARGE_INTESTINE	123829 →	+0.669	+2.649	.021	.046	3	1
LARGE_INTESTINE	50869 →	+0.464	+2.649	.028	.046	3	1
LARGE_INTESTINE	GW-2580 →	+0.361	+2.786	.004	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Lestaurtinib by PARP8 expression — LARGE_INTESTINE

Explore this box plot interactively →