PARP6

Across TCGA pan-cancer cohorts, PARP6 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PARP6 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PARP6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PARP6 expression acts as an unfavorable survival marker.

LSCC and PDAC are the cancer types where PARP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.593	0.951	.005	18	view →
PDAC	DFS	Median	All	0.256	0.683	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PARP6–LSCC (OS)

Open the LSCC breakdown →