PARP6

Across TCGA patient cohorts, PARP6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,650 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PARP6-associated genes across cancer lineages are FAM216B, SSR4P1, and LPXN. Each is linked with PARP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP6-to-partner and partner-to-PARP6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PARP6 versus FAM216B in HNSC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP6→partner) and Y-score (partner→PARP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FAM216B →	+1.343	+0.536	.007	.001	3	2
HNSC	SSR4P1 →	-0.502	-0.710	.002	<.001	3	2
PDAC	LPXN →	-0.834	-0.794	.003	.005	3	2
PDAC	RPS2P6 →	+0.263	+0.806	.001	.007	3	2
BRCA	H2AZP1 →	-0.838	-1.270	<.001	.004	3	2
BRCA	ILF2P2 →	-1.001	-1.624	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,650 associations by consensus.

PARP6 vs FAM216B — HNSC

Explore this scatter interactively →