PARP6

Across TCGA patient cohorts, PARP6 mutation is significantly associated with the RNA expression of many other genes, with 3,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP6-associated genes across cancer lineages are ZWILCH, PRIM1, and ASAH2B. Each is linked with PARP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP6-to-partner and partner-to-PARP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWILCH grouped by PARP6-low versus PARP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP6→partner) and Y-score (partner→PARP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZWILCH →	+0.744	+3.341	.005	.005	3	2
UCEC	PRIM1 →	+0.760	+3.850	<.001	<.001	3	2
SKCM	ASAH2B →	+0.643	+3.353	<.001	.005	3	2
LUSC	RNU1-74P →	+0.365	+3.651	<.001	.003	3	2
SKCM	RNA5SP496 →	+0.303	+2.643	<.001	.003	3	2
SKCM	MIR190B →	+0.172	+3.356	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,048 associations by consensus.

ZWILCH by PARP6 expression — SKCM

Explore this box plot interactively →