PARP4

Across TCGA cell cohorts, PARP4 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP4-associated genes across cancer lineages are MFRP, MRPL2, and MSGN1. Each is linked with PARP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP4-to-partner and partner-to-PARP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFRP grouped by PARP4-low versus PARP4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP4→partner) and Y-score (partner→PARP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MFRP →	+0.017	+3.285	.003	.009	3	2
LARGE_INTESTINE	MRPL2 →	+0.573	+3.212	<.001	.006	3	2
LARGE_INTESTINE	MSGN1 →	+0.054	+2.760	.001	.003	3	2
OESOPHAGUS	SHCBP1L →	+0.086	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	GFRA4 →	+0.020	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	SCGB1C1 →	+0.088	+4.108	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

MFRP by PARP4 expression — BLOOD_Myeloma

Explore this box plot interactively →